Treatment of Verrucous Carcinoma of the Lower Lip with Topical Imiquimod (Aldara®) and Debulking Therapy
نویسندگان
چکیده
Verrucous carcinoma is an unusual, non-metastasizing, distinct variant of squamous cell carcinoma composed of four subtypes according to the site of occurrence: oral type, anogenital type, plantar type, and other cutaneous sites. Oral type verrucous carcinoma usually shows slow progression with a low incidence of metastases. Treatment of verrcous carcinoma is challenging; multiple medical and surgical therapies are often attempted, with limited success. We reported on 2 cases of verrucous carcinoma of the lip treated with topical imiquimod and debulking therapy.
منابع مشابه
Treatment of actinic cheilitis with imiquimod 5% and a retractor on the lower lip: clinical and histological outcomes in 5 patients.
Imiquimod 5% (Aldara, 3M Healthcare Ltd.) is a topically applied immune response modifier used in the treatment of superficial basal cell carcinoma, actinic keratosis, and genital warts. We reviewed the casenotes of 5 patients with histologically confirmed dysplastic lower lips who had been treated with topical imiquimod. Each patient was provided with a specially designed lower lip retractor t...
متن کاملTreatment of verrucous carcinoma with imiquimod and CO2 laser ablation.
An 82-year-old female patient presented with a large perianal hyperkeratotic tumor extending into the anal canal. Staging did not reveal any metastatic spread. Diagnosis of verrucous carcinoma or Buschke-Löwenstein tumor, respectively, was based on typical clinical and histologic features. Moreover, human papillomavirus 6b DNA sequences could be detected by PCR. Surgical excision could not be p...
متن کاملClinical Medicine Reviews in Oncology
Imiquimod 5% cream (Aldara) was approved by the Food and Drug Administration for the treatment of non-facial superficial basal cell carcinomas (sBCC) in 2004 and has become one of the most commonly used topical treatments for this variant of basal cell carcinoma. Application of the cream once a day, 5 days per week for 6 weeks has demonstrated a clinical and histological cure rate approximating...
متن کامل[Erythema multiforme due to 5% imiquimod cream].
Imiquimod 5% cream (Aldara, 3M Pharmaceuticals) is a topical immunomodulator approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinoma, although it is also used off-label in clinical practice for other dermatologic conditions. Although local side effects are most frequent, it can also produce systemic side effects. We describe the case of a patient who...
متن کاملIntravenous cidofovir for recalcitrant verruca vulgaris in the setting of HIV.
A 34-year-old human immunodeficiency virus (HIV)– seropositive man with a history of Kaposi sarcoma and ocular cytomegalovirus presented with an 8to 10-month history of multiple, progressively enlarging verrucous papules on the proximal nail fold and the distal interphalangeal joint of the right third finger (Figure 1). His CD4 cell count was 21/μL during retroviral therapy. A clinical diagnosi...
متن کامل